| Date | Place | Visitor | Scores |
| 27.08.2005 | Home | AO Egaleo more.. | 1:1 |
| 12.09.2005 | Away | Larisa more.. | 0:2 |
| 17.09.2005 | Home | Olympiakos Piraeus more.. | 0:3 |
| 25.09.2005 | Away | Ionikos Nikea more.. | 1:2 |
| 01.10.2005 | Home | Panathinaikos Athen more.. | 2:4 |
| 16.10.2005 | Away | Panionios Athen more.. | 0:1 |
| 23.10.2005 | Away | Levadiakos more.. | 0:1 |
| 29.10.2005 | Home | Akratitos Liosion more.. | 2:0 |
| 05.11.2005 | Away | AEK Athen more.. | 0:2 |
| 20.11.2005 | Home | PAOK Saloniki more.. | 1:1 |
| 27.11.2005 | Away | OFI Heraklion Crete more.. | 0:0 |
| 03.12.2005 | Home | Apollon Kalamaria more.. | 0:0 |
| 11.12.2005 | Away | AO Xanthi more.. | 2:2 |
| 18.12.2005 | Home | Atromitos Halkidona more.. | 2:3 |
| 08.01.2006 | Home | Iraklis Saloniki more.. | 0:0 |
| 22.01.2006 | Away | AO Egaleo more.. | 0:1 |
| 28.01.2006 | Home | Larisa more.. | 2:1 |
| 06.02.2006 | Away | Olympiakos Piraeus more.. | 1:2 |
| 11.02.2006 | Home | Ionikos Nikea more.. | 3:3 |
| 19.02.2006 | Away | Panathinaikos Athen more.. | 0:2 |
| 25.02.2006 | Home | Panionios Athen more.. | 1:2 |
| 04.03.2006 | Home | Levadiakos more.. | 3:2 |
| 12.03.2006 | Away | Akratitos Liosion more.. | 0:1 |
| 18.03.2006 | Home | AEK Athen more.. | 1:4 |
| 25.03.2006 | Away | PAOK Saloniki more.. | 1:2 |
| 02.04.2006 | Home | OFI Heraklion Crete more.. | 0:1 |
| 09.04.2006 | Away | Apollon Kalamaria more.. | 0:0 |
| 16.04.2006 | Home | AO Xanthi more.. | 2:1 |
| 30.04.2006 | Away | Atromitos Halkidona more.. | 1:2 |
| 13.05.2006 | Away | Iraklis Saloniki more.. | 2:3 |
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